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Originally from Shiraz, Iran, Abe holds a B.Sc. in cellular and molecular biology and M.Sc. in nano-biomimetics from the University of Tehran, Iran. As the first STEM student in his family, he has honed his computational and experimental skills in molecular and cell biology, functional genomics, systems biology, and gene regulation. His work includes integrating CRISPR screening and multi-omics datasets to study drug mechanisms in cancer cells. Notably, he developed ScreenPro2, a tool that enables flexible analysis of high-content CRISPR screening datasets....

Understanding the intricacies of DNA methylation is essential for unraveling the complexities of epigenetic regulation in various biological processes, including cancer development and treatment. In the subsequent sections, we delve into the impact of decitabine, a DNA demethylating agent, on global DNA methylation patterns and RNA dynamics upon drug treatment in the context of acute myeloid leukemia (AML) cancer treatment. Background Decitabine, a DNA demethylating agent, is a drug with an epigenetic therapy mechanism of action and an FDA approved strategy to treat high-risk patients with AML cancer....